Nowhere was this felt as intensely as in management of autism and related conditions. Thankfully, after more years of continuing education and application of principles not taught in medical school, I now gain immense satisfaction in offering services to autistic children and their families, given that I have determined, as have other CAM (Complementary and Alternative Medicine) doctors, that a difference can and has been made.
No doubt autism is a complex interplay between genetics and environment, with not all children on the spectrum requiring the same level of support. As a spectrum condition, there is wide variability in symptom severity and management needs. For cases presenting to me, I came to conceptualize autism as a disease template from which to explain many of our modern illnesses, and applied to it the methods I was using to address other chronic conditions with a toxic-immune component. Over time, I was exposed to research about glutathione, glutamate levels, and gluten metabolites; about autism case management, casein partial digestion, and cerebral folate.
Key to assisting ASD patients is recognizing the variations in important biochemical pathways that can be supported with targeted nutrient therapy, such as with the proper forms of both B12 and folate. For me, the diagnostic category is important, but so is understanding the underpinnings of any condition. With autism and related disorders, the emphasis on mitochondrial function, immune dysregulation (including mast cell activation), the gut-microbiome-brain axis, oxidative stress, and environmental toxicants is where I place my focus in clinical practice. These in turn affect the brain, with neuroinflammation at the core.
Ultimately, I came to bear witness to the fact that the ability to dramatically improve the life (and remove the label) of an autistic child in need of more intensive support has a profound impact on not only the patient, but also the patient’s family and community.
Applying principles of integrative medicine, including nutrition-based therapies, in fact extends the positive impact to all levels of society, given that improvements in the condition can relieve many burdens. The approach is integrative, comprehensive, and can be complicated – any management scheme should never be more burdensome to patient and/or family than the condition itself – but I’ve seen firsthand that parents can apply these therapies with favourable outcomes. The following case illustrates that point:
I first met T. when he was three years, two months old. A diagnosis of Autism Spectrum Disorder (ASD) had been made eight months prior. His parents – attentive, knowledgeable, supportive, and cooperative – provided a clear history of regression in speech development at age 18 months. The boy had gone from speaking an 8 to 10 single word vocabulary – to not speaking at all. Further observations:
T.’s parents requested an unconventional medicine approach to their son’s illness, and consented to the use of complementary therapies administered through my office.
His informed parents had already started the child on probiotics, essential fatty acids, B vitamins, and other supplements prior to his visit with me. At the first meeting, we interactively outlined a plan for management, with a focus on biological, nutrition-based medicine. The first phase was to assess (by history, exam, a urine organic acid profile, and blood analysis) and correct yeast-related abnormalities. A gluten-free, casein-free, sugar-free diet was prescribed.
With bowel function improved, we moved to phase two: pro-oxidant (including metal burden) assessment and treatment. Simultaneously, a 2 week prescription of the anti-fungal preparation Fluconazole was recommended, followed by botanicals including grapefruit seed extract, garlic, and the homeopathic Fungisode from Genestra. Immune function was also regulated, using Imunovir.
After 3 months, T.’s parents consented to the non-standard provocative urine toxic elements test, which showed very elevated mercury excretion. The parents requested regular visits for metal depuration, and nutrients for glutathione support (the organic acid test indicated low levels) were issued. (Glutathione is a naturally produced antioxidant that assists in the removal of mercury, pesticides, PCBs, PBBs, and other chemicals. It also protects mitochondrial function.)
After 5 months of treatment, language development was progressing, with less prompting and more spontaneity. Also toilet training was better, with much improved stool consistency. The parents reported “dramatic changes,” including increased play interaction.
After 6 months, his IBI (Intensive Behavioural Intervention) therapists “could not believe the improvement” in speech and general development. Transdermal glutathione and carnosine (a nutrient with reported benefits for speech development in ASD) were suggested, and checks on fungal activity continued, with intervention as required.
After 9 months, the parents noted major improvements in language acquisition, and a repeat urine toxic metals test showed almost normal levels. He was switched to a solely oral metal excretion program, which included a combination of DMSA with lipoic acid from a compounding pharmacy, used on a 3 day on / 11 days off rotation with close monitoring of lab parameters and mineral status.
By 1 year, a psychological assessment was performed by a developmental disabilities specialist, who noted “considerable improvement in his ASD characteristics,” and that, “he is much less likely to display hyperactivity.”
Routine follow-up testing for cell counts, heavy metals, mineral levels, and liver and kidney function occurred from the outset, with continued surveillance through the following year during application of the supplementation program. After 23 months, T. no longer qualified for government funding, since autism was “no longer a diagnosis in writing,” according to his parents. T.’s parents were ecstatic with the overall outcome.
By age six, T. was fully integrated in a regular school and not requiring any extra assistance. He communicated normally and easily, with his humorous, interactive personality in full bloom. There were no longer any signs of autism, cognitively or socially. In fact, the teachers at his new school were not even aware that a diagnosis of autism once applied to him. Medically, the diagnosis has been removed.
I am optimistic that in the future:
Disclaimer: The information contained in this article includes the opinions of Dr. Gannage and is for educational purposes only. One should always seek personalized advice from a qualified practitioner before making the dietary and behaviour changes listed, as the needs and medical status of individuals are highly variable. Dr. Gannage is not responsible for any adverse events that might occur from application of any of the therapies outlined in this article.
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What a great information...thanks a lot... I am also going to start bio medical treatment for my son who regressed in all areas at 18 months of age..
Any latest case study of autism treatment with l glutathione, please update
I have a 5 1/2 year old grandson who had Autism. He is said to be non verbal. He dies make some sounds in his own language od sounds. If you were to look at him you would not think he had autism.
He dies do do a lot of autistic things with his hands, lining your his toys in his order, he is having a hard time with his potty training and consistently at home with his mom and us helping him he could do better I think. He eats a lot of Carbohydrates and drinks Sodas, Tea, HC Punch etc .
He had been detoxed early on in in diagnosis and that brought about him to jabbering and being like himself after his 18 month shots. He was about 22 months when he was texted and has attended ABA Therapy ever since. What do you suggest we do for him to improve ?
It's weird how right after my son's MMR vaccine he went dark... But of course it's just a coincidence as they say
Another Success Story! 25 years ago, I noticed the doctor giving my son a vaccine on the day of his birth. Other factors played into my son's slow progression into autism. However, when he was 1 or 2 years old a nurse gave him 2 differing types of vaccines in one visit. She said it would save a trip. The next day, he didn't respond to his name, he paced in a repetitive pattern throughout our house, and he even started banging his head against his bedroom wall while he stood in his crib. He was nonverbal. I filmed his behavior. It was soul-crushing to see. An expert (doctor) came to our house after that and measured his I.Q. way below normal 50 or so. I knew he had severe, disabling Autism at that point. However, we had dial up internet access, and did our research showing that in Japan, they began giving vaccines after the age of two, and SID's and other related conditions decreased. This gave us the inspiration to travel to a Chelation doctor (not this one) with all our findings. We brought in a lot of paperwork, because he said he never chelated a toddler. The doctor was old and good. He had us send hair and feces samples to an independent lab. The findings came back a week later that showed heavy metal levels that were very high, although mercury was in the normal range. The conclusion was that the mercury had already bound in his system, and did not come out in the samples. For one year I allowed the doctor to administer DMSA along with a lot of vitamin regimen to protect his organs. The doctor knew his stuff. After some time my son started behaving more normally, and one day walked out of his room to say, "Hi Dad." I teared up. I knew we had a genius on our hands, because he was making electronics work on a broken toy he had. However, I told my wife we would only have treatment for him for one year in total due to my fear of organ damage. So we did. He continued on with an autistic way about him, but it turned more into Aspergers. By the time he was six he read the entire Torah one summer. Now at the age of 25 he is the assistant Supervisor EMT at a Chemical Plant. NOTE: DESPITE OUR SUCCESS PLEASE BE CAREFUL WITH CHELATION. Still we are grateful, and glad we took action when we did. A lot of the heavy metals were expelled, and now some good doctors are using better techniques to get even better results. It appears the doctor here knows is really great. We've never met, but thanks for your work on other patients Dr. Gannage.